Jun 1, 2016 at 18:11 o\clock

Studies suggest drugs for advanced lung, skin cancers extend patients' lives

NEW YORK -  Two new drugs that help the immune system fight some of the deadliest cancers are helping patients live years longer than older treatments, according to clinical trial results that should further boost confidence in this approach to oncology.

Merck & Co showed that its Keytruda drug helped many patients with advanced melanoma survive at least three years, while Bristol-Myers demonstrated that Opdivo can prolong life for a significant number of patients with advanced lung cancer by at least two years.

The results were released on Wednesday ahead of the American Society of Clinical Oncology meeting in Chicago next month.

Keytruda and Opdivo are among the first wave of successful immuno-oncology drugs with a list price of about $150,000 a year. They work by blocking a protein called PD-1 that tumors use to evade detection by the immune system.

In one study, researchers following 655 patients with advanced melanoma reported 40 percent of those who received Keytruda were still alive three years after beginning treatment.

Prior to the appearance of these new drugs, this deadliest form of skin cancer had no effective treatments and most patients died less than a year after the disease spread to other parts of the body.

"For 40 percent of these patients to be alive at three years is a big deal," Dr. Daniel Hayes, a University of Michigan oncologist who will take the role of ASCO president next month, said in an interview. "It makes us wonder if we can use the word 'cure'" for some patients.

Survival with Keytruda was similar regardless of whether patients had previously been treated with an older immunotherapy called Yervoy from Bristol-Myers. Among newly-diagnosed patients who had not received any prior treatment, 45 percent were still alive after three years.

In a separate study testing Keytruda against Yervoy in advanced melanoma, 55 percent of those who received the Merck drug were alive after two years versus 43 percent for Bristol's Yervoy.

"These are previously unattainable results, but could represent the new normal," said Dr. Roger Dansey, who oversees late-stage oncology drug development for Merck.

Data was made available through abstracts, or brief https://500px.com/methadoneUSA - Methadone Clinic - descriptions, of the studies to be formally presented at the ASCO meeting.

Both forms of NSCLC are associated with smoking and relatively short-term survival. NSCLC accounts for more than 80 percent of lung cancers.

The incidence of serious side effects in the two studies was much lower for Opdivo than chemotherapy, the company said.

"With long-term follow-up, we're not seeing any increase in Opdivo related side effects," Botwood said.

Opdivo and Keytruda, both injectable biotech drugs, are fast becoming the second-line standard of care for NSCLC after chemotherapy, as well as the treatment of choice for melanoma that has spread.

They are also being tested against a wide variety of cancers, and in combinations with many https://disqus.com/by/methadone_clinic_usa/ - Can Methadone - drugs, including other immunotherapies and other types of cancer medicines.

May 30, 2016 at 01:02 o\clock

More Babies Born Addicted to Opiates

More babies in the U.S. are being born with symptoms of opiate withdrawal than were seen a decade ago, researchers found.

The number of newborns with neonatal abstinence syndrome (NAS) tripled between 2000 and 2009, and the number of mothers using opiates at the time of delivery rose five-fold over that period, Dr. Stephen Patrick of the University of Michigan in Ann Arbor and colleagues reported online in the Journal of the American Medical Association.

"This serves as a reminder that this is really a public health emergency that requires attention from multiple levels from the federal government, from state government, and from researchers," Patrick told The JAMA Report.

Read this story on www.medpagetoday.com.

Recent data have shown that about 16 percent of pregnant teens and about 7.5 percent of pregnant women ages 18 to 25 use illicit drugs. Most neonate withdrawal problems have been tied to maternal opiate use, although other drugs have been implicated, the researchers wrote.

To determine the incidence of NAS and maternal drug use, Patrick and colleagues looked at data from the Kids' Inpatient Database and the Nationwide Inpatient Sample, both from 2000-2009.

They found that the incidence of NAS rose significantly over that time, from 1.20 per 1,000 births to 3.39 per 1,000.

Maternal opiate use at delivery also increased during that period, jumping from 1.19 to 5.63 per 1,000 births.

"This observation is consistent with the trend of increasing opiate use across the U.S., which is not limited to illicit drugs," Patrick and colleagues wrote, citing CDC data showing a quadrupling of sales and deaths related to opiate painkillers between 1999 and 2008.

Data also showed that mothers on opiates at the time of delivery were more likely to be covered by Medicaid than other insurance, and Medicaid was also the primary payor for the majority of hospital charges for NAS in infants.

Because Medicaid is administered by the states, they "are in a unique position to be innovative in solutions to decrease the number of opiates that are used in the state and to make sure care is more efficient for babies after they are born," Patrick told The JAMA Report.

Newborns with NAS were more likely than other newborns to have low birthweight, respiratory complications, feeding difficulties, and seizures, the researchers noted.

And those difficulties were https://sites.google.com/site/methadoneclinicusa/Methadone-Clinic-USA-Information - Methadone - costly: Mean hospital charges for these infants rose from $39,400 to $53,400 between 2000 and 2009, compared with a rise from $6,600 to $9,500 for all other hospital births over that time.

Patrick and colleagues noted that length-of-stay for these infants remained unchanged over that time, at a mean of about 16 days.

The findings "call for increased public health measures to reduce antenatal exposure to opiates across the U.S.," they wrote.

The study was limited by the accuracy of the data in the databases and by the potential for increased clinician awareness of the condition contributing to the increase in incidence.

In an accompanying editorial, Marie Hayes PhD and Dr. Mark Brown of Eastern Maine Medical Center in Bangor said more research is needed http://methadoneclinicusa.flavors.me/ - Prescription - into pharmacologic treatments for addicted mothers and identification and management strategies for newborns with NAS.

"Future directions in NAS research must address the need for clinical trials of new medications to establish optimal protocols for maternal opiate dependence, with particular focus on methadone treatment induction of the mother early in pregnancy, maternal adherence to treatment, ancillary alcohol use monitoring, and psychiatric care," they wrote.

"Postnatally, early identification and aggressive opiate replacement in infants with early https://drive.google.com/open?id=0BwMhQ3_7KHNJMVVOM3U3TDV0eG8 - Opioid Treatment - signs of NAS may help to decrease severity and length of stay," they added.

May 27, 2016 at 07:54 o\clock

Real Estate :: 5 Tricks to Rehabbing a Fixer Upper

Rehabbing a fixer upper is a great way to make extra money or a sustainable https://delicious.com/methadoneusa - Mg Methadone - income. The problem however is that you can't just go out and purchase the very first fixer upper you see. Instead, you have to be smart about your fixer https://ifttt.com/p/methadoneclinicusausa/shared - Treat Opiate - upper purchases and only buy those properties that you can realistically fix and profit from right away. In this article, we'll provide you with 5 proven tips you can use to make cash from a fixer upper.

1. Understand that your mission is not to make your property the best house on the block. Instead, it is to upgrade the property so that it is at least equal to the other houses on the block. That is, your renovated fixer upper should be able to "hold its own" once you're finished fixing it up. For instance, if every house on the block has professional landscaping and the house you're considering has dead grass and weeds galore, your first priority will be to improve the landscaping so that it looks comparable to your neighbors.

2. When choosing a fixer upper, make sure you're competent to do the necessary fixer upper repairs and that they're within your budget. That is, if you are not an expert electrician and don't have the funds to hire a master electrician to fix large wiring problem for an apartment complex then it would probably be better NOT to buy that particular fixer upper property. If you ignore this advice, you could https://medium.com/@methadoneclinicusa - Heroin Methadone - end shelling out more money than you've budgeted which will dip into your profit margins.

4. If you don't have the funds to complete all necessary repairs, either don't buy that particular property, repair what you can, be willing to sell the property "as is" and profit less, or offer buyers a renovation stipend.

5. Purchase fixer upper properties that have good resale value. For instance, studio condos tend to be very hard to sell in good or bad markets whereas 3-4 bedroom houses with at least 2 baths tend to sell really well, regardless of the economy. In conclusion, if you're serious about fixer upper investments then you must rehab it so it holds its own, work within your budgetary constraints, complete necessary repairs that are within your competency, purchase properties with good resale values. Good luck!

May 24, 2016 at 06:09 o\clock

Alcohol Addiction


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Alcohol addiction is a serious problem that affects millions of people each year. It is important to recognize the warning signs of an addiction. Let's take a look at some of these signs and symptoms, and the steps necessary to stop the abuse of alcohol.

Alcohol is a part of many people's lives. Most restaurants serve alcoholic beverages and it is present at most sporting events and office parties. Many people can have a drink or two and stop there with no problem at all. For many people however, this is not the case. One drink can quickly lead to many more and some people simply do not have the ability to control their alcohol consumption. Studies have shown that people that come from an alcoholic family, have an increased risk of becoming problem drinkers. This leads us to believe that genetics plays some role in this addictive process. Stress is also a leading factor in one's ability to control their consumption of alcohol. Many people turn to the bottle as a way to manage the stress that is present in their lives. Unfortunately, alcohol cannot make these problems disappear, they are still present and often drinking creates new problems. Many family members simply cannot take the up and down roller coaster ride of living with someone who is a problem drinker or an alcoholic. These families may have financial difficulties due to the alcoholic missing work or being fired from their job due to drinking. Abuse is prevalent in many homes where alcoholism exists, because the person drinking is unable to control their behavior while drinking. Many affable people have completely different personalities once they begin to drink. Just because someone has a problem with alcohol, it does not mean that they cannot recover and lead a full, normal life. It is important to recognize the symptoms of alcohol abuse, so that help for the addiction can be obtained before it is too late.

The following are a list of things that may indicate you or someone you care about has a problem with alcohol.

l. Withdrawing from friends and family.

2. A preoccupation with obtaining alcohol.

3. Numerous failed attempts to quit drinking.

4. Unexplained swings in moods or strange behavior.

5. Blaming others for problems or the ability to be unable to quit drinking.

6. Anger or depression.

Alcohol addiction can also have many different physical symptoms as well. The following things are a list of some of them.

1. Redness and puffiness of https://sites.google.com/site/localsubstanceabusetreatment/ - Center For Alcohol And Drug - the face or eyes.

2. Abdominal pain.

3. Sick or shaking feeling, especially when not drinking.

4. Driving while intoxicated, this may result in legal troubles.

5. An increased tolerance to alcohol, and the need to drink more to feel the "buzz".

6. Periods of not being able to remember things or conversations, "blackout" periods.

7. Flushing of the skin from an excessive intake of alcohol.

8. Missing school or work due to hangovers or periods of being intoxicated.

If you or someone you know, has any of these symptoms it is important to get help right away. There are many people who have conquered their alcohol addiction and have went on to lead happy, healthy lives.

Author's Bio: 

To read more about symptoms and how to overcome drug, alcohol, or porn addiction then visit the comprehensive addiction site.

Feb 15, 2016 at 21:15 o\clock

Why On-Site Sewage Facilities Fail By Meredi Wagner-Hoehn

by: talllaborer2068   Keywords: solid, waste

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This method http://www.dailystrength.org/people/4427967/journal/14102157 - how to tell if your septic tank is full - to cut water waste . It operates with fresh or salt water. Then inside the plant, the metals are leached from your crushed resources... the resulting option is thickened and solid waste is separated from your metals solution.

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If the technology might be scaled up, it could become just another power generation technology that powers the electrical grid and, at the identical time, creating oil, has, and a soil conditioner. The steps may sound very easy to read, but implementation becomes equally difficult if attention not paid to detail. The steps may sound quite simple to read, but implementation becomes equally difficult if attention not paid to detail. Recycling may seem a bit tedious at first, but once you practice it everyday, you an excellent habit that you can take at home. The professionals at WWS may help you obtain your wastewater treatment and disposal on track.