Jan 26, 2016 at 08:16 o\clock

Foam Granulation part 3 - plastic sheet extrusion companies -

A study at pilot-scale flow prices compared foamed-binder addition and direct liquid-injection on granulation. A methylcellulose binder was employed at two concentrations, 6% and 11%, in accordance with a-lactose monohydrate powder. Two screws were examined in the work to produce differing axial compression attributes with changing flow pace: one with a single pair of mixing components making lower axial compression and a second with two pairs in series to provide a far more restrictive flow path and higher axial compression. The granule homes from the study showed that comparable sizes and intragranular porosity were attained by either method, provided appropriate conditions were used. The lowered requirement for liquid in the process was a comparable finding compared to that found with high-shear batch mixers.

Wet granulation in twin screw extrusion machinery has several key positive aspects over conventional strategies, but to advance in acceptance for GMP production, its operations must be better understood and challenges regarding process steadiness have to be solved. Constant foam granulation is a new, robust technique that solves the process surging problems that relate to poor powder wetting by typical, liquid-addition methods. The superior spreading tendency of foam in granulation, versus the quick soaking design of liquids, produces even more wetted powders and escalates the overall lubricity of the process uniformly, which benefits use behavior of the minimizes and machine dissipative heating of the product. With comparable particle real estate to regular wet granulation, foam granulation gives formulators higher flexibility in achieving production goals.

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