Summary of the use of breastfeeding albendazole
Containing drugs albendazole: Albenza
The level and effectiveness of albendazole and breastfeeding
Summary of breastfeeding with
Albendazole
and its metabolites into the milk secretion is minimal. Informal
consultative group, the World Health Organization concluded that the
single oral dose of albendazole may be given breast-feeding women.
Drug concentration
Maternal levels. Thirty-three women who were at 2 weeks and infants under 6 months of breastfeeding, albendazole were given a single oral dose of 400 mg. 6, 12, 24 milk samples obtained pre-dose and 36 hours after administration. 6 hours after administration, maternal blood samples. Fenbendazole, albendazole sulfoxide, albendazole sulfone, and maternal blood and milk samples were determined. Albendazole Sulfoxide pharmacokinetic parameters were calculated, from the women who provided three or more of the milk samples of 20 data. The average peak concentration 352 micrograms of milk / liter, an average of 6.9 hours. It has a half-life of 12.4 hours breast milk. The concentration of albendazole sulfoxide, 36 hours after the dose, the average 57 micrograms / L; albendazole and albendazole sulfone in the milk for less than "" (<292 nanomoles / liter) I estimate that exclusive breast fed infants less exposed. More than 0.1 mg / in 36 hours after albendazole sulfoxide kg, a dose of 400 mg or less of the maternal ivermectin injection. as an infant dose of less than 1.5% of maternal weight adjusted dose.
Poor absorption of albendazole is widely extensive first-pass CYP3A4 sulfoxide metabolite of albendazole metabolism of active metabolite of oral drugs. This is not the further metabolism of active metabolite, albendazole sulfone.
